Hepatic Glutathione Reductase

Mammalian Selenoprotein Thioredoxin-glutathione Reductase

Molecular basis of glutathione reductase deficiency in human blood cells Short title: Human glutathione reductase deficiency

NMK performed research, collected and analyzed data and wrote the paper; RvZ collected patient material, performed research and analyzed data; MdB performed sequence analysis and analyzed data; GM performed sequence analysis; HV performed patient RBC analysis; NB treated one patient and collected data; CL treated one patient, collected data and wrote a clinical report; KMD interviewed three pat...

Dimethyl Fumarate Induces Glutathione Recycling by Upregulation of Glutathione Reductase

Neuronal degeneration in multiple sclerosis has been linked to oxidative stress. Dimethyl fumarate (DMF) is an effective oral therapeutic option shown to reduce disease activity and progression in patients with relapsing-remitting multiple sclerosis. DMF activates the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) leading to increased synthesis of the major cellular ant...

Glutathione reductase is inhibited by acetaminophen-glutathione conjugate in vitro.

The aim of the present work was to investigate a new mechanism likely contributing to the toxic action of acetaminophen, especially to explore the possible inhibition of glutathione reductase through an acetaminophen-glutathione conjugate (APAP-SG). APAP-SG conjugate was synthesized by organic synthesis and purified by column chromatography. The inhibitory effect of the conjugate on two types o...

Liver glutathione and glutathione reductase response of endotoxin-treated mice.

The decrease in the level of liver glutathione (GSH) in endotoxin-treated mice was in part due to formation of glutathione disulfide (GSSG). An electron-generating system (EGS) had no effect when incubated with soluble liver extracts from normal controls but resulted in recovery of GSH amounting to 25% in endotoxin-treated animals. Incubation in the absence of the EGS caused a decline of 16% in...